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Although the underlying mechanisms of metastasis remain unclear, recent studies have demonstrated that a small subset of tumor cells known as cancer stem cells CSCswhich exhibit similar characteristics to normal stem cells including self-renewal and pluripotencymay be involved in cancer invasion and metastasis 3. SOX2 and Oct4 are important for maintaining self-renewal and pluripotency in pluripotent stem cells 6. KLF4, which is involved in tissue development, differentiation and maintenance of homeostasis, may act as either an oncogene or a tumor suppressor in certain types of cancer, including gastric adenocarcinoma and colon cancer 7 — 9.

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